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Four new indole-terpenoids  (1–4)  named encindolene A, 18- O -methyl-encindolene A, encindolene B, and encindolene C, as well as three known analogs  (5–7) , were isolated from the fungus  Penicillium  sp. HFF16 from the rhizosphere soil of  Cynanchum bungei  Decne. The structures of compounds including absolute configurations were elucidated by spectroscopic data and electronic circular dichroism (ECD) analysis. Anti-inflammatory activity evaluation revealed that compounds  1–7  inhibit the production of nitric oxide with IC 50  values of 79.4, 49.7, 81.3, 40.2, 86.7, 90.1, and 54.4 μM, respectively, and decrease the levels of tumor necrosis factor-α, interleukin-6 contents in lipopolysaccharide-induced RAW264.7 macrophages.

Indole-Terpenoids With Anti-inflammatory Activities From Penicillium sp. HFF16 Associated With the Rhizosphere Soil of Cynanchum bungei Decne