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The use of probiotics and antifungal capabilities of the lactic acid bacteria (LAB) isolated from different niches is a strategy to prepare functional cultures and biopreservatives for food/feed industries. In the present study, LAB strains isolated from an Indian traditional fermented food, Pozha, were evaluated for their probiotic properties and biocontrol potential. A total of 20 LAB isolates were selected from Pozha samples collected aseptically and screened for their antagonistic activity against  Fusarium verticillioides . Among the bioactive isolates,  Lacticaseibacillus brevis  MYSN105 showed the highest antifungal activity  in vitro , causing some morphological alterations such as damaged mycelia and deformed conidia. Cell-free supernatant (CFS) from  L. brevis  MYSN105 at 16% concentration effectively reduced the mycelial biomass to 0.369 g compared to 1.938 g in control. Likewise, the conidial germination was inhibited to 20.12%, and the seed treatment using CFS induced a reduction of spore count to 4.1 × 10 6  spores/ml compared to 1.1 × 10 9  spores/ml for untreated seeds. The internal transcribed spacer (ITS) copy number of  F. verticillioides  decreased to 5.73 × 10 7  and 9.026 × 10 7  by  L. brevis  MYSN105 and CFS treatment, respectively, compared to 8.94 × 10 10  in control. The  L. brevis  MYSN105 showed high tolerance to  in vitro  gastrointestinal conditions and exhibited high adhesive abilities to intestinal epithelial cell lines. The comparative genome analysis demonstrated specific secondary metabolite region coding for bacteriocin and T3PKS (type III polyketide synthase) possibly related to survival and antimicrobial activity in the gut environment. Our results suggest that  L. brevis  MYSN105 has promising probiotic features and could be potentially used for developing biological control formulations to minimize  F. verticillioides  contamination and improve food safety measures.

Probiotic and Antifungal Attributes of Levilactobacillus brevis MYSN105, Isolated From an Indian Traditional Fermented Food Pozha