English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Extended-spectrum β-lactamases (ESBLs) production and (fluoro)quinolone (FQ) resistance among  Salmonella  pose a public health threat. The objective of this study was the phenotypic and genotypic characterization of an ESBL-producing and nalidixic acid-resistant  Salmonella enterica  serovar Gloucester isolate (serotype 4:i:l,w) of sequence type 34 (ST34) from ready-to-eat (RTE) meat products in China. Whole-genome short and long read sequencing (HiSeq and MinION) results showed that it contained  bla  CTX–M–  55 ,  qnrS1 , and  tetB  genes, with  bla  CTX–M–  55  and  qnrS1  located in chromosomal IS 26 -mediated composite transposon (IS 26 – qnrS1 –IS 3 –Tn 3 – orf – bla  CTX–M–  55 –IS Ecp1 –IS 26 ). The same genetic structure was found in the chromosome of  S. enterica  subsp.  enterica  serovar Typhimurium strain and in several plasmids of  Escherichia coli , indicating that the IS 26 -mediated composite transposon in the chromosome of  S.  Gloucester may originate from plasmids of  E. coli  and possess the ability to disseminate to  Salmonella  and other bacterial species. Besides, the structural unit  qnrS1 –IS 3 –Tn 3 – orf – bla  CTX–M–  55  was also observed to be linked with IS Kpn19  in both the chromosomes and plasmids of various bacteria species, highlighting the contribution of the insertion sequences (IS 26  and IS Kpn19 ) to the co-dissemination of  bla  CTX–M–  55  and  qnrS1 . To our knowledge, this is the first description of chromosomal  bla  CTX–M–  55  and  qnrS  in  S.  Gloucester from RTE meat products. Our work expands the host range and provides additional evidence of the co-transfer of  bla  CTX–M–  55  and  qnrS1  among different species of  Salmonella  through the food chain.

frontiers in microbiology

First Report of a Foodborne Salmonella enterica Serovar Gloucester (4:i:l,w) ST34 Strain Harboring blaCTX–M–55 and qnrS Genes Located in IS26-Mediated Composite Transposon