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More than 95% of invasive  Candida  infections are caused by four  Candida  spp. ( C. albicans, C. glabrata, C. tropicalis, C. parapsilosis ). C-type lectin-like receptors (CLRs), such as Dectin-1, Dectin-2, and Mincle mediate immune responses to  C. albicans . Dectin-1 promotes clearance of  C. albicans, C. glabrata, C. tropicalis , and  C. parapsilosis , however, dependence on Dectin-1 for specific immune responses varies with the different  Candida  spp. Dectin-2 is important for host immunity to  C. albicans  and  C. glabrata , and Mincle is important for the immune response to  C. albicans.  However, whether Dectin-2 drives host immunity to  C. tropicalis  or  C. parapsilosis , and whether Mincle mediates host immunity to  C. glabrata, C. tropicalis  or  C. parapsilosis  is unknown. Therefore, we compared the roles of Dectin-2 and Mincle in response to these four  Candida  spp. We demonstrate that these four  Candida  spp. cell walls have differential mannan contents. Mincle and Dectin-2 play a key role in regulating cytokine production in response to these four  Candida  spp. and Dectin-2 is also important for clearance of all four  Candida  spp. during systemic infection. However, Mincle was only important for clearance of  C. tropicalis  during systemic infection. Our data indicate that multiple  Candida  spp. have different mannan contents, and dependence on the mannan-detecting CLRs, Mincle, and Dectin-2 varies between different  Candida  spp. during systemic infection.

Dependence on Mincle and Dectin-2 Varies With Multiple Candida Species During Systemic Infection