English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Helicobacter pylori  harbors a dipeptide (Dpp) transporter consisting of a substrate-binding protein (DppA), two permeases (DppB and C), and two ATPases (DppD and F). The Dpp transporter is responsible for the transportation of dipeptides and short peptides. We found that its expression is important for the growth of  H .  pylori . To understand the role of the Dpp transporter in the pathogenesis of  H .  pylori , the expression of virulence factors and  H .  pylori -induced IL-8 production were investigated in  H. pylori  wild-type and isogenic  H. pylori  Dpp transporter mutants. We found that expression of CagA was downregulated, while expression of type 4 secretion system (T4SS) components was upregulated in Dpp transporter mutants. The DppA mutant strain expressed higher levels of outer membrane proteins (OMPs), including BabA, HopZ, OipA, and SabA, and showed a higher adhesion level to gastric epithelial AGS cells compared with the  H .  pylori  26695 wild-type strain. After infection of AGS cells,  H .  pylori  Δ dppA  induced a higher level of NF-κB activation and IL-8 production compared with wild-type. These results suggested that in addition to supporting the growth of  H .  pylori , the Dpp transporter causes bacteria to alter the expression of virulence factors and reduces  H .  pylori -induced NF-κB activation and IL-8 production in gastric epithelial cells.

The Role of a Dipeptide Transporter in the Virulence of Human Pathogen, Helicobacter pylori