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Staphylococcus epidermidis  is an opportunistic pathogen, and its biofilm formation ability is an important virulent factor. Quercetin, a typical flavonoid ubiquitously used in dietary supplementation, is known for its antioxidant property, but its anti-biofilm activity against  S. epidermidis  remains unknown. In this study, the anti-biofilm activity of quercetin was investigated using  S. epidermidis  ATCC35984, a strong biofilm-positive strain. An attempt was made to disclose the mechanisms of the anti-biofilm activity of quercetin.  S. epidermidis  exhibited a less cell surface hydrophobicity after quercetin treatment. Also, quercetin effectively inhibited  S. epidermidis  cells from adhering to the glass slides. Quercetin downregulated the intercellular adhesion ( ica ) locus and then polysaccharide intercellular adhesin (PIA) production was reduced. Therefore,  S. epidermidis  cells became less hydrophobic, which supported quercetin’s anti-biofilm effect. Our study suggests that quercetin from plants be given further attention as a potential anti-biofilm agent against the biofilm formation of  S. epidermidis , even biofilm infections of other bacteria.

Quercetin Inhibits Biofilm Formation by Decreasing the Production of EPS and Altering the Composition of EPS in Staphylococcus epidermidis