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Macrolide-resistant  Streptococcus suis  is highly prevalent worldwide. The acquisition of the  erm (B) gene mediated by mobile genetic elements (MGEs) in particular integrative and conjugative elements (ICEs) is recognized as the main reason for the rapid spread of macrolide-resistant streptococcal strains. However, knowledge about different  erm (B)-carrying elements responsible for the widespread of macrolide resistance and their transferability in  S. suis  remains poorly understood. In the present study, two  erm (B)- and  tet (O)-harboring putative ICEs, designated as ICE Ssu YSB17_ rplL  and ICE Ssu YSJ15_ rplL , and a novel  erm (B)- and  aadE-spw -like-carrying genomic island (GI), named GI Ssu JHJ17_ rpsI , were identified to be excised from the chromosome and transferred among  S. suis  strains with different serotypes. ICE Ssu YSB17_ rplL  and ICE Ssu YSJ15_ rplL  were integrated downstream the  rplL  gene, a conserve locus of the ICE Sa 2603 family. GI Ssu JHJ17_ rpsI , with no genes belonging to the conjugation module, was integrated into the site of  rpsI . All transconjugants did not exhibit obvious fitness cost by growth curve and competition assays when compared with the recipient. The results demonstrate that different  erm (B)-carrying elements were presented and highlight the role of these elements in the dissemination of macrolide resistance in  S. suis .

Horizontal Transfer of Different erm(B)-Carrying Mobile Elements Among Streptococcus suis Strains With Different Serotypes