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The respiratory electron transport chain (ETC) of  Mycobacterium smegmatis  is terminated with two terminal oxidases, the  aa  3  cytochrome  c  oxidase and the cytochrome  bd  quinol oxidase. The  bd  quinol oxidase with a higher binding affinity for O 2  than the  aa  3  oxidase is known to play an important role in aerobic respiration under oxygen-limiting conditions. Using relevant  crp1  ( MSMEG_6189 ) and  crp2  ( MSMEG_0539 ) mutant strains of  M. smegmatis , we demonstrated that Crp1 plays a predominant role in induction of the  cydAB  operon under ETC-inhibitory conditions. Two Crp-binding sequences were identified upstream of the  cydA  gene, both of which are necessary for induction of  cydAB  expression under ETC-inhibitory conditions. The intracellular level of cAMP in  M. smegmatis  was found to be increased under ETC-inhibitory conditions. The  crp2  gene was found to be negatively regulated by Crp1 and Crp2, which appears to lead to significantly low cellular abundance of Crp2 relative to Crp1 in  M. smegmatis . Our RNA sequencing analyses suggest that in addition to the SigF partner switching system, Crp1 is involved in induction of gene expression in  M. smegmatis  exposed to ETC-inhibitory conditions.

frontiers in microbiology

Induction of the cydAB Operon Encoding the bd Quinol Oxidase Under Respiration-Inhibitory Conditions by the Major cAMP Receptor Protein MSMEG_6189 in Mycobacterium smegmatis