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The skin constitutes with its microbiota the first line of body defense against exogenous stress including air pollution. Especially in urban or sub-urban areas, it is continuously exposed to many environmental pollutants including gaseous nitrogen dioxide (gNO 2 ). Nowadays, it is well established that air pollution has major effects on the human skin, inducing various diseases often associated with microbial dysbiosis. However, very few is known about the impact of pollutants on skin microbiota. In this study, a new approach was adopted, by considering the alteration of the cutaneous microbiota by air pollutants as an indirect action of the harmful molecules on the skin. The effects of gNO 2  on this bacterial skin microbiota was investigated using a device developed to mimic the real-life contact of the gNO 2  with bacteria on the surface of the skin. Five strains of human skin commensal bacteria were considered, namely  Staphylococcus aureus  MFP03,  Staphylococcus epidermidis  MFP04,  Staphylococcus capitis  MFP08,  Pseudomonas fluorescens  MFP05, and  Corynebacterium tuberculostearicum  CIP102622. Bacteria were exposed to high concentration of gNO 2  (10 or 80 ppm) over a short period of 2 h inside the gas exposure device. The physiological, morphological, and molecular responses of the bacteria after the gas exposure were assessed and compared between the different strains and the two gNO 2  concentrations. A highly significant deleterious effect of gNO 2  was highlighted, particularly for  S. capitis  MFP08 and  C. tuberculostearicum  CIP102622, while  S. aureus  MFP03 seems to be the less sensitive strain. It appeared that the impact of this nitrosative stress differs according to the bacterial species and the gNO 2  concentration. Thus the exposition to gNO 2  as an air pollutant could contribute to dysbiosis, which would affect skin homeostasis. The response of the microbiota to the nitrosative stress could be involved in some pathologies such as atopic dermatitis.

Deleterious Effects of an Air Pollutant (NO2) on a Selection of Commensal Skin Bacterial Strains, Potential Contributor to Dysbiosis?