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Pseudomonas aeruginosa  is an opportunistic pathogen associated with life-threatening nosocomial and community-acquired infections. Antibiotic resistance is an immediate threat to public health and demands an urgent action to discovering new antimicrobial agents. One of the best alternatives for pre-clinical tests with animal models is the greater wax moth  Galleria mellonella . Here, we evaluated the antipseudomonal activity of silver nanoparticles (AgNPs) against  P. aeruginosa  strain UCBPP-PA14 using  G. mellonella larvae . The AgNPs were synthesized through a non-toxic biogenic process involving microorganism fermentation. The effect of AgNPs was assessed through characterization and quantification of the hemocytic response, nodulation and phenoloxidase cascade. On average, 80% of the  larvae  infected with  P. aeruginosa  and prophylactically treated with nanoparticles survived. Both the specific and total  larvae  hemocyte counts were restored in the treated group. In addition, the nodulation process and the phenoloxidase cascade were less exacerbated when the  larvae  were exposed to the silver nanoparticles. AgNPs protect the  larvae  from  P. aeruginosa  infection by directly killing the bacteria and indirectly by preventing an exacerbated immunological response against the pathogen. Our results suggest that the prophylactic use of AgNPs has a strong protective activity against  P. aeruginosa  infection.

In vivo Activity of Silver Nanoparticles Against Pseudomonas aeruginosa Infection in Galleria mellonella