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Studies involving antimicrobial-coated endotracheal tubes are scarce, and new approaches to control multidrug-resistant  Pseudomonas aeruginosa  biofilm on these devices should be investigated. In this study, five new  P. aeruginosa  bacteriophages from domestic sewage were isolated. All of them belong to the order  Caudovirales ,  Myoviridae  family. They are pH and heat stable and produce 27 to 46 particles after a latent period of 30 min at 37°C. Their dsDNA genome (ranging from ∼62 to ∼65 kb) encodes 65 to 89 different putative proteins. They exhibit a broad lytic spectrum and infect 69.7% of the  P. aeruginosa  strains tested. All the bacteriophages were able to reduce the growth of  P. aeruginosa  strains in planktonic form. The bacteriophages were also able to reduce the biofilm viability rates and the metabolic activity of  P. aeruginosa  strains in a model of biofilms associated with endotracheal tubes. In addition, scanning electron microscopy micrographs showed disrupted biofilms and cell debris after treatment of bacteriophages, revealing remarkable biofilm reduction. The lytic activity on multidrug-resistant  P. aeruginosa  biofilm indicates that the isolated bacteriophages might be considered as good candidates for therapeutic studies and for the application of bacteriophage-encoded products.

Identification and Characterization of New Bacteriophages to Control Multidrug-Resistant Pseudomonas aeruginosa Biofilm on Endotracheal Tubes