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We identified an antimicrobial peptide (AMP) from  Lactobacillus acidophilus  that was antagonistic to  Aeromonas hydrophila .  In vitro  studies such as well-diffusion and field trials revealed that the AMP was active against  A. hydrophila . The field trials of AMP using  A. hydrophila -infected  Channa striatus  with a mannone oligosaccharide (MOS) prebiotic,  A. hydrophila  antigens,  A. hydrophila -infected fish serum,  L. acidophilus , and  Lactobacillus  cell free-supernatant (LABS-CFS) on an indicator organism further revealed that the antimicrobial agent could protect  C .  striatus . Other than the AMP, none of the above were able to eliminate the infectious agent  A. hydrophila , and were only able to delay the death rate for 3–4 days. Thus, we conclude that the AMP is antagonistic to  A. hydrophila  and may be used for treatment of  A. hydrophila  infections. Subsequent  L. acidophilus  whole-genome sequence analyses enabled an understanding of the (probable) gene arrangement and its location on the chromosome. This information may be useful in the generation of recombinant peptides to produce larger quantities for treatment.

Lactobacillus acidophilus Antimicrobial Peptide Is Antagonistic to Aeromonas hydrophila