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Campylobacter  species are zoonotic pathogens and the leading cause of bacterial enteritis worldwide. With the increase of antimicrobial resistance to fluoroquinolones and macrolides, they have been identified by the World Health Organization (WHO) as high-priority antimicrobial-resistant pathogens. There is currently little known about the prevalence and antimicrobial resistance characteristics of  Campylobacter  species in Beijing. In this study, we performed a 2-year surveillance of  Campylobacter  in Beijing, China. We used multilocus sequence typing (MLST) and antimicrobial susceptibility testing to analyze 236  Campylobacter  isolates recovered from 230 clinical infectious cases in Beijing between 2017 and 2018. The  Campylobacter  isolation rate in diarrhea patients was 7.81%, with higher isolation rates in male patients than female patients and in autumn compared with other seasons. We identified 125 sequence types (STs) of 23 cloning complexes (CCs) among the 236 isolates, including four new alleles and 19 new STs. The most commonly isolated STs of  Campylobacter jejuni  were ST-22 and ST-760 (4.50%), and the most commonly isolated ST of  Campylobacter coli  was ST-9227 (16.67%). We also compared our isolates with clinical  Campylobacter  isolates from other countries in Asia, CC-353 of  Campylobacter coli  was found in eight countries, CC-1034 and CC-1287 of  Campylobacter coli  were found only in China. All  C. jejuni  isolates were resistant to at least one antimicrobial.  C. jejuni  showed the highest rate of resistance toward ciprofloxacin (94.50%), followed by tetracycline (93.50%), and nalidixic acid (92.00%), while  C. coli  showed highest resistance toward ciprofloxacin (94.44%) and tetracycline (94.44%) followed by nalidixic acid (88.89%). The most commonly observed MDR combination of  C. jejuni  were quinolone, phenicol and tetracycline (11.50%), while the most commonly observed MDR combination of  C. coli  were macrolide, quinolone, phenicol, tetracycline and lincosamide (30.56%). Surveillance of molecular characterization will provide important information for prevention of  Campylobacter  infection. This study enhances insight into  Campylobacter  infections in diarrheal patients, with relevance for treatment regimens in Beijing.

Multilocus Sequence Types and Antimicrobial Resistance of Campylobacter jejuni and C. coli Isolates of Human Patients From Beijing, China, 2017–2018