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Veillonella atypica  is a bacterium that is present in the gut and the oral cavity of mammals and plays diverse roles in different niches. A recent study demonstrated that  Veillonella  is highly associated with marathon running and approved that  V. atypica  gavage improves treadmill run time in mice, revealing that  V. atypica  has a high biotechnological potential in improving athlete performance. However, a comprehensive analysis of the genetic diversity, function traits, and genome editing method of  V. atypica  remains elusive. In the present study, we conducted a systemically comparative analysis of the genetic datasets of nine  V. atypica  strains. The pan-genome of  V. atypica  consisted of 2,065 homologous clusters and exhibited an open pan-genome structure. A phylogenetic analysis of  V. atypica  with two different categories revealed that  V. atypica  OK5 was the most distant from the other eight  V. atypica  strains. A total of 43 orthologous genes were identified as CAZyme genes and grouped into 23 CAZyme families. The CAZyme components derived from accessory clusters contributed to the differences in the ability of the nine  V. atypica  strains to utilize carbohydrates. An integrated analysis of the metabolic pathways of  V. atypica  suggested that  V. atypica  strains harbored vancomycin resistance and were involved in several biosynthesis pathways of secondary metabolites. The  V. atypica  strains harbored four main  Cas  proteins, namely, CAS-Type IIIA, CAS-Type IIA, CAS-Type IIC, and CAS-Type IIID. This pilot study provides an in-depth understanding of and a fundamental knowledge about the biology of  V. atypica  that allow the possibility to increase the biotechnological potential of this bacterium.

Comparative Genomics Uncovers the Genetic Diversity and Characters of Veillonella atypica and Provides Insights Into Its Potential Applications