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Probiotic  Clostridium butyricum  could affect lipid metabolism in broilers. However, it is not clear whether  C. butyricum  could improve lipid metabolism through shaping gut microbiota and bile acid (BA) profile of laying hens. We aimed to evaluate the contributions of gut microbiota and BA profile to the potential effect of  C. butyricum  on lipid metabolism of aged laying hens. A total of 192 60-week-old Hy-Line Brown laying hens were divided into two groups (eight replicates per group). Birds were fed a basal diet supplemented with 0 or 2.7 g/kg  C. butyricum  (1.0 × 10 9  CFU/g). Samples were collected at the end of week 8 of the experiment. The results showed elevated ( P  < 0.05) concentrations of glucagon-like peptide 1, insulin and thyroid hormones in serum responded to  C. butyricum  addition, which also decreased ( P  < 0.05) hepatic free fatty acids contents, as well as increased ( P  < 0.05) the expression of hepatic acyl-CoA oxidase, farnesoid X receptor (FXR) and PPARα.  C. butyricum  addition increased ( P  < 0.05)  Bacteroidetes  abundance but tended to decrease ( P  < 0.10)  Firmicutes  abundance in the ileum. Besides,  C. butyricum  addition resulted in higher ( P  < 0.05) abundances of  Clostridia  ( Clostridiales ) and  Prevotellaceae , concurrent with an increasing trend ( P  < 0.10) of  Bifidobacteriaceae  abundance and decreased the abundances of several harmful bacteria such as  Klebsiella  ( P  < 0.05). Regarding ileal BA profile, there was a reduced ( P  < 0.05) content of tauro-α-muricholic acid, increased ( P  < 0.05) contents of tauroursodeoxycholic acid and lithocholic acid, along with increasing trends ( P  < 0.10) of glycochenodeoxycholic acid and hyodeoxycholic acid contents due to  C. butyricum  addition, which also increased ( P  < 0.05) ileal FXR expression. Collectively, supplemental  C. butyricum  accelerated hepatic fatty acid oxidation, and shaped gut microbiota and BA profile, thus reducing fat deposition in the liver of aged laying hens.

Supplemental Clostridium butyricum Modulates Lipid Metabolism Through Shaping Gut Microbiota and Bile Acid Profile of Aged Laying Hens