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In most bacteria, iron plays a vital role in pathogenesis processes. To support survival and infection,  Streptococcus pneumoniae  has evolved three ABC transporters, PiaABC, PiuABC, and PitABC. Moreover, indirect evidence supports that operon 804 may be a novel ABC transporter in  S. pneumoniae . We have recently described the identification of lipoprotein SPD_1609 in operon 804; however, whether the SPD_1609 protein affects the virulence of  S. pneumoniae  has not yet been studied. In the present work, alignment analysis showed that lipoprotein SPD_1609 is conserved in a variety of gram-positive bacteria, and deletion of the  spd_1609  gene led to a reduction in adherence and invasion of  S. pneumoniae  to host cells. RT-qPCR assays indicated that deletion of the  spd_1609  gene resulted in decreased expression of genes involved in colonization. Furthermore, decreased virulence in a mouse bacteremia infection model caused by the loss of the lipoprotein encoded by  spd_1609  was also demonstrated. Overall, these data provide insights into the functional role of lipoprotein SPD_1609 in pneumococcal pathogenesis, suggesting its possibility to be developed as a novel  S. pneumoniae  vaccine candidate.

Lipoprotein SPD_1609 of Streptococcus pneumoniae Promotes Adherence and Invasion to Epithelial Cells Contributing to Bacterial Virulence