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Objectives  To explore the microbiome of the prostatic fluid in high prostate-specific antigen (PSA) patients.    Patients and Methods  The microbiome profiles of prostatic fluid samples from 32 prostate cancer (PCa) patients and 27 non-PCa people were assessed. Microbiome analysis was assessed by massive 16S ribosomal RNA gene sequencing.    Results  Compared with the NCA group, the microbial diversity was lower in the CA group. There were no specific microbial species in the CA group or NCA group. However, many species, such as those in the genera  Alkaliphilus ,  Enterobacter ,  Lactococcus ,  Cronobacter ,  Carnobacterium , and  Streptococcus , showed a significant difference between the CA group and NCA group.    Conclusion  The prostate contains reduced bacteria, suggesting a possible pathophysiological correlation between the composition of the microbiome and PCa. Meanwhile, this study uncovered that the microbiome may be beneficial in maintaining the stability of the microenvironment of the prostate and provides interesting perspectives for the identification of novel biomarkers in high-PSA patients.

The Microbiome of Prostate Fluid Is Associated With Prostate Cancer