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The emergence and increase in prevalence of resistance to cephalosporins amongst isolates of  Salmonella  from food animals imposes a public health threat. The aim of the present study was to investigate the prevalence and characteristics of CTX-M-producing  Salmonella  isolates from raw meat and food animals. 27 of 152 (17.76%)  Salmonella  isolates were ESBL-positive including 21/70 (30%) from food animals and 6/82 (7.32%) from raw meat. CTX-M-55 was the most prevalent ESBL type observed (12/27, 44.44%). 7 of 12 CTX-M-55-positive  Salmonella  isolates were  Salmonella  Indiana, 2 were  Salmonella  Typhimurium, 2 were  Salmonella  Chester, and the remaining isolate was not typeable. Eight CTX-M-55-positive  Salmonella  isolates were highly resistant to fluoroquinolones (MIC CIP  = 64 ug/mL) and co-harbored  aac(6’)-Ib-cr  and  oqxAB . Most of the CTX-M-55 positive isolates (11/12) carried  bla  CTX-M-55  genes on the chromosome, with the remaining isolate carrying this gene on a transferable 280 kb IncHI2 plasmid. A chromosomal  bla  CTX-M-55  gene from one isolate transferred onto a 250 kb IncHI2 plasmid which was subsequently conjugated into recipient strain J53. PFGE and MLST profiles showed a wide range of strain types were carrying  bla  CTX-M-55 . Our study demonstrates the emergence and prevalence of foodborne  Salmonella  harboring a chromosomally located  bla  CTX-M-55  in China. The co-existence of PMQR genes with  bla  CTX-M-55  in  Salmonella  isolates suggests co-selection and dissemination of resistance to both fluoroquinolones and cephalosporins in  Salmonella  via the food chain in China represents a public health concern.

The Emergence of Chromosomally Located blaCTX-M-55 in Salmonella From Foodborne Animals in China