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This study presents three novel integrons In1394, In1395, and In1443, three novel unit transposons Tn 6392 , Tn 6393 , and Tn 6403 , one novel conjugative element (ICE) Tn 6413 , and the first sequenced IncP-7 resistance plasmid p1160-VIM from clinical  Pseudomonas aeruginosa . Detailed sequence comparison of p1160-VIM (carrying Tn 6392  and Tn 6393 ) and Tn 6413  (carrying Tn 6403 ) with related elements were performed. Tn 6392 , Tn 6393 , and Tn 6403  were generated from integration of In1394 (carrying  bla  VIM–24 ), In1395 and In1443 (carrying  bla  VIM–4 ) into prototype Tn 3 -family unit transposons Tn 5563 , Tn 1403 , and Tn 6346 , respectively. To the best of our knowledge, this is the first report of a  bla  VIM–24 -carrying  P. aeruginosa  isolate.

frontiers in microbiology

Genetic Characterization of a blaVIM–24-Carrying IncP-7β Plasmid p1160-VIM and a blaVIM–4-Harboring Integrative and Conjugative Element Tn6413 From Clinical Pseudomonas aeruginosa