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Few bacteria are resistant to tetracycline and can even biodegrade tetracycline in the environment. In this study, we isolated a bacterium  Pandoraea  sp. XY-2, which could biodegrade 74% tetracycline at pH 7.0 and 30°C within 6 days. Thereafter, we determined the whole genome sequence of  Pandoraea  sp. XY-2 genome is a single circular chromosome of 5.06 Mb in size. Genomic annotation showed that two AA6 family members-encoding genes and nine glutathione S-transferase (GSTs)-encoding genes could be relevant to tetracycline biodegradation. In addition, the average nucleotide identities (ANI) analysis between the genomes of  Pandoraea  sp. XY-2 and other  Pandoraea  spp. revealed that  Pandoraea  sp. XY-2 belongs to a new species. Moreover, comparative genome analysis of 36  Pandoraea  strains identified the pan and specific genes, numerous single nucleotide polymorphisms (SNPs), insertions, and deletion variations (InDels) and different syntenial relationships in the genome of  Pandoraea  sp. XY-2. Finally, the evolution and the origin analysis of genes related to tetracycline resistance revealed that the six  tetA (48) genes and two specificgenes  tetG  and  tetR  in  Pandoraea  sp. XY-2 were acquired by horizontal gene transfer (HGT) events from sources related to  Paraburkholderia, Burkholderia, Caballeronia, Salmonella, Vibrio, Proteobacteria, Pseudomonas, Acinetobacter, Flavimaricola , and some unidentified sources. As a new species,  Pandoraea  sp. XY-2 will be an excellent resource for the bioremediation of tetracycline-contaminated environment.

Whole Genome Sequencing and Comparative Genomics Analyses of Pandoraea sp. XY-2, a New Species Capable of Biodegrade Tetracycline