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Infections due to New Delhi metallo-beta lactamase (NDM)-7-producing  Escherichia coli  are infrequent and sporadic. In this study, we report one case of recurrent urinary tract infection caused by  bla  NDM-7 -producing  E. coli  belonging to phylogenetic group A, sequence type (ST) 167. In this study, we aimed to describe the genotype and phenotype of  bla  NDM-7 -producing  E. coli  in China. The isolate exhibited resistance to β-lactam antimicrobials, trimethoprim-sulfamethoxazole, quinolones, and aminoglycosides.  bla  NDM-7  is located on a conjugative plasmid designated pJN05NDM-7 belonging to type IncX3. pJN05NDM-7 was fully sequenced and compared with all publicly available  bla  NDM-7 -harboring plasmids. pJN05NDM-7 is almost identical to pKpN01-NDM7 and pKW53T, although the plasmids are geographically unrelated. The comparison of IncX3 plasmids harboring  bla  NDM  in China showed high similarity, with genetic differences within insertion fragments. Notably, the differences in plasmids of animal and human origin were insignificant, because only one plasmid showed deletion inside the ISAba125 region compared with pJN05NDM7. Our study demonstrates that  E. coli  carrying IncX3 plasmids play an important role as a reservoir and in the spread of  bla  NDM . Further studies should be performed to control the dissemination of  bla  NDM  among food animals.

frontiers in microbiology

Genotypic and Phenotypic Characterization of IncX3 Plasmid Carrying blaNDM-7 in Escherichia coli Sequence Type 167 Isolated From a Patient With Urinary Tract Infection