English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Mycobacterium tuberculosis  is the etiologic agent of tuberculosis. The demand for new chemotherapeutics with unique mechanisms of action to treat (multi)resistant strains is an urgent need. The objective of this work was to test the effect of manganese(II) and copper(II) phenanthroline/dicarboxylate complexes against  M. tuberculosis . The water-soluble Mn(II) complexes, [Mn 2 (oda)(phen) 4 (H 2 O) 2 ][Mn 2 (oda)(phen) 4 (oda) 2 ]·4H 2 O ( 1 ) and {[Mn(3,6,9-tdda)(phen) 2 ]·3H 2 O·EtOH}n ( 3 ) (odaH 2  = octanedioic acid, phen = 1,10-phenanthroline, tddaH 2  = 3,6,9-trioxaundecanedioic acid), and water-insoluble complexes, [Mn(ph)(phen)(H 2 O) 2 ] ( 5 ), [Mn(ph)(phen) 2 (H 2 O)]·4H 2 O ( 6 ), [Mn 2 (isoph) 2 (phen) 3 ]·4H 2 O ( 7 ), {[Mn(phen) 2 (H 2 O) 2 ]} 2 (isoph) 2 (phen)·12H 2 O ( 8 ) and [Mn(tereph)(phen) 2 ]·5H 2 O ( 9 ) (phH 2  = phthalic acid, isophH 2  = isophthalic acid, terephH 2  = terephthalic acid), robustly inhibited the viability of  M. tuberculosis  strains, H37Rv and CDC1551. The water-soluble Cu(II) analog of ( 1 ), [Cu 2 (oda)(phen) 4 ](ClO 4 ) 2 ·2.76H 2 O·EtOH ( 2 ), was significantly less effective against both strains. Whilst ( 3 ) retarded H37Rv growth much better than its soluble Cu(II) equivalent, {[Cu(3,6,9-tdda)(phen) 2 ]·3H 2 O·EtOH}n ( 4 ), both were equally efficient against CDC1551. VERO and A549 mammalian cells were highly tolerant to the Mn(II) complexes, culminating in high selectivity index (SI) values. Significantly,  in vivo  studies using  Galleria mellonella  larvae indicated that the metal complexes were minimally toxic to the larvae. The Mn(II) complexes presented low MICs and high SI values (up to 1347), indicating their auspicious potential as novel antitubercular lead agents.

frontiers in microbiology

Unprecedented in Vitro Antitubercular Activitiy of Manganese(II) Complexes Containing 1,10-Phenanthroline and Dicarboxylate Ligands: Increased Activity, Superior Selectivity, and Lower Toxicity in Comparison to Their Copper(II) Analogs