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Erythritol is a natural sweetener produced by microorganisms as an osmoprotectant. It belongs to the group of polyols and it can be utilized by the oleaginous yeast  Yarrowia lipolytica . Despite the recent identification of the transcription factor of erythritol utilization ( EUF1 ), the metabolic pathway of erythritol catabolism remains unknown. In this study we identified a new gene,  YALI0F01628g , involved in erythritol assimilation.  In silico  analysis showed that  YALI0F01628g  is a putative isomerase and it is localized in the same region as  EUF1 . qRT-PCR analysis of  Y. lipolytica  showed a significant increase in  YALI0F01628 g expression during growth on erythritol and after overexpression of  EUF1 . Moreover, the deletion strain  ΔF01628  showed significantly impaired erythritol assimilation, whereas synthesis of erythritol remained unchanged. The results showed that  YALI0F1628g  is involved in erythritol assimilation; thus we named the gene  EYI1 . Moreover, we suggest the metabolic pathway of erythritol assimilation in yeast  Y. lipolytica .

A Role of a Newly Identified Isomerase From Yarrowia lipolytica in Erythritol Catabolism