English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Antisense RNAs from complementary strands of protein coding genes regulate the expression of genes involved in many cellular processes. Using deep sequencing analysis of the  Salmonella enterica  serovar Typhi ( S.  Typhi) transcriptome, a novel antisense RNA encoded on the strand complementary to the  rpoH  gene was revealed. In this study, the molecular features of this antisense RNA were assessed using northern blotting and rapid amplification of cDNA ends. The 3,508 nt sequence of RNA was identified as the antisense RNA of the  rpoH  gene and was named ArpH. ArpH was found to attenuate the invasion of HeLa cells by  S.  Typhi by regulating the expression of SPI-1 genes. In an  rpoH  mutant strain, the invasive capacity of  S.  Typhi was increased, whereas overexpression of ArpH positively regulates  rpoH  mRNA levels. Results of this study suggest that the  cis -encoded antisense RNA ArpH is likely to affect the invasive capacity of  S.  Typhi by regulating the expression of  rpoH .

Identification and Characterization of a Cis Antisense RNA of the rpoH Gene of Salmonella enterica Serovar Typhi