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Forty-five KPC-producing  Enterobacteriaceae  strains were isolated from multiple departments in a Chinese public hospital from 2014 to 2015. Genome sequencing of four representative strains, namely  Proteus mirabilis  GN2,  Serratia marcescens  GN26,  Morganella morganii  GN28, and  Klebsiella aerogenes  E20, indicated the presence of  bla  KPC-2 -carrying IncX6 plasmids pGN2-KPC, pGN26-KPC, pGN28-KPC, and pE20-KPC in the four strains, respectively. These plasmids were genetically closely related to one another and to the only previously sequenced IncX6 plasmid, pKPC3_SZ. Each of the plasmids carried a single accessory module containing the  bla  KPC-2/3 -carrying ΔTn 6296  derivatives. The ΔTn 6292  element from pGN26-KPC also contained  qnrS , which was absent from all other plasmids. Overall, pKPC3_SZ-like  bla  KPC -carrying IncX6 plasmids were detected by PCR in 44.4% of the KPC-producing isolates, which included  K. aerogenes, P. mirabilis, S. marcescens, M. morganii, Escherichia coli , and  Klebsiella pneumoniae , and were obtained from six different departments of the hospital. Data presented herein provided insights into the genomic diversity and evolution of IncX6 plasmids, as well as the dissemination and epidemiology of  bla  KPC -carrying IncX6 plasmids among  Enterobacteriaceae  in a hospital setting.

Dissemination of KPC-2-Encoding IncX6 Plasmids Among Multiple Enterobacteriaceae Species in a Single Chinese Hospital