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Objectives:  Sequence type 1193 is emerging as a new, virulent and resistant lineage among fluoroquinolone resistant  Escherichia coli  (FQ r   E. coli ). In this study, we investigated the prevalence and molecular characteristics of this clone isolated from a Chinese university hospital.   Methods:  73 phylogenetic group B2-FQ r -non-ST131 isolates were collected from August 2014 and August 2015 at a Chinese university hospital. Isolates were screened for ST1193 by multilocus sequence typing.  E. coli  ST1193 then underwent lactose fermentation determination, susceptibility testing, virulence genotyping, PCR-based O typing, pulsed-field gel electrophoresis (PFGE) and FQ r  mechanism analysis.   Results:  Of 73 B2-FQ r -non ST131  E. coli  isolates, 69.9% ( n  = 51) were ST1193. 90.2% (46/51) of ST1193 isolates were O75 serotype and 96.1% (49/51) of the ST1193 isolates were lactose non-fermenters. 35 clusters were identified by PFGE. ST1193 isolates exhibited a set of 3 conserved mutations defining quinolone-resistance determining region substitutions ( gyrA  S83L, D87N, and  parC  S80I). The most frequent VF genes detected in these  E. coli  ST1193 isolates were  fyuA  (yersiniabactin, 96.1%),  fimH  (type 1 fimbriae, 94.1%),  iutA  (iron uptake gene, 90.2%),  kpsMT II  (group II capsule, 90.2%),  kpsK1  (K1 capsule, 86.3%) and PAI.   Conclusion:  ST1193 lineage accounts for the majority of group B2-FQ r -non-ST131  E. coli  clinical isolates. Most of the ST1193 are serotype O75 and lactose non-fermenting. Strategic surveillance and control schemes are needed in the future for this newly emerging clone of  E. coli : B2-FQ r -ST1193.

Molecular Characteristics of ST1193 Clone among Phylogenetic Group B2 Non-ST131 Fluoroquinolone-Resistant Escherichia coli