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Chromobacterium violaceum  is an abundant component of the soil and water microbiota in tropical and subtropical regions around the world. For many years, it was mainly known as a producer of violacein and as a reporter for the discovery of quorum sensing molecules. However,  C. violaceum  has recently emerged as an important model of an environmental opportunistic pathogen. Its high virulence in human infections and a mouse infection model involves the possession of several predicted virulence traits, including two type III secretion systems (T3SSs). In this article, in addition to providing an update on the new clinical cases of human  C. violaceum  infections, we will focus on recent advances in understanding the molecular mechanisms regarding  C. violaceum  pathogenesis. It has been demonstrated that the  C. violaceum  Cpi-1 T3SS plays a pivotal role in interaction with host cells. It is required for the secretion of effector proteins and is the agonist recognized by the Nod-like receptor CARD domain-containing protein 4 (NLRC4) inflammasome from innate immune cells. Pyroptosis and its release of hepatocytes for killing by neutrophils are key events required for the clearance of  C. violaceum . Given the prominent role of T3SSs in  C. violaceum  virulence, we examine their occurrence in the  Chromobacterium  genus, taking advantage of several draft genome sequences of  Chromobacterium  species that have recently become available. Our finding that the Cpi-1 T3SS is widespread among  Chromobacterium  species points toward the pathogenic potential of this genus for humans or to novel roles of the T3SS in the interaction of  Chromobacterium  species with other organisms.

Chromobacterium violaceum Pathogenicity: Updates and Insights from Genome Sequencing of Novel Chromobacterium Species