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In this work, we searched for an effective probiotic that can help control intestinal infection, particularly enterotoxigenic  Escherichia coli  K88 (ETEC) invasion, in giant panda ( Ailuropoda melanoleuca ). As a potential probiotic strain,  Lactobacillus plantarum  BSGP201683 ( L. plantarum  G83) was isolated from the feces of giant panda and proven beneficial  in vitro . This study was aimed to evaluate the protective effect of  L. plantarum  G83 in mice challenged with ETEC. The mice were orally administered with 0.2 mL of PBS containing  L. plantarum  G83 at 0 colony-forming units (cfu) mL −1  (control; negative control, ETEC group), 5.0 × 10 8  cfu mL −1  (LDLP), 5.0 × 10 9  cfu mL −1  (MDLP), and 5.0 × 10 10  cfu mL −1  (HDLP) for 14 consecutive days. At day 15, the mice (LDLP, MDLP, HDLP, and ETEC groups) were challenged with ETEC and assessed at 0, 24, and 144 h. Animal health status; chemical and biological intestinal barriers; and body weight were measured. Results showed that  L. plantarum  G83 supplementation protected the mouse gut mainly by attenuating inflammation and improving the gut microflora. Most indices significantly changed at 24 h after challenge compared to those at 0 and 144 h. All treatment groups showed inhibited plasma diamine oxidase activity and  D -lactate concentration. Tight-junction protein expression was down-regulated, and interleukin (IL)-1β, IL-6, IL-8, TLR4, and MyD88 levels were up-regulated in the jejunum in the LDLP and MDLP groups. The number of the  Enterobacteriaceae  family and the heat-labile enterotoxin (LT) gene decreased ( P  < 0.05) in the colons in the LDLP and MDLP groups. All data indicated that  L. plantarum  G83 could attenuate acute intestinal inflammation caused by ETEC infection, and the low and intermediate doses were superior to the high dose. These findings suggested that  L. plantarum  G83 may serve as a protective probiotic for intestinal disease and merits further investigation.

frontiers in microbiology

Lactobacillus plantarum BSGP201683 Isolated from Giant Panda Feces Attenuated Inflammation and Improved Gut Microflora in Mice Challenged with Enterotoxigenic Escherichia coli