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Schistosoma japonicum  ( S. japonicum ) is a worldwide spread pathogen which penetrates host skin and then induces several diseases in infected host, such as fibrosis, formation of granulomas, hepatocirrhosis, and hepatomegaly. In present study, for the first time, transcriptomic profiles of mouse livers and skins infected by fork-tailed  S. japonicum  cercaria or non-fork-tailed  S. japonicum  cercaria were analyzed by using RNA-seq. The present findings demonstrated that transcriptomic landscapes of livers and skins infected by fork-tailed  S. japonicum  cercaria or non-fork-tailed  S. japonicum  cercaria were different.  S. japonicum  has great influence on hepatic metabolic processes. Fork-tailed  S. japonicum  cercaria upregulated hepatic metabolic processes, while non-fork-tailed  S. japonicum  cercaria downregulated hepatic metabolic processes. For the metabolism process or the metabolism enzyme expressional change, the pharmacokinetics of host could be changed during  S. japonicum  infection, regardless the biotypes of  S. japonicum  cercariae. The changes of infected skins focused on upregulation of immune response. During the  S. japonicum  skin infection period, fork-tailed  S. japonicum  cercaria infection induced stronger immune response comparing with that immune response triggered by non-fork-tailed  S. japonicum  cercaria. The transcription factor enrichment analysis showed that Irf7, Stat1 and Stat2 could play important roles in gene regulation during fork-tailed  S. japonicum  cercaria infection.

Comparative Study of Transcriptome Profiles of Mouse Livers and Skins Infected by Fork-Tailed or Non-Fork-Tailed Schistosoma japonicum