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In recent decades, the identification of small non-coding RNAs in bacteria has revealed an important regulatory mechanism of gene expression involved in the response to environmental signals and to the control of virulence. In the family  Vibrionaceae , which includes several human and animal pathogens, small non-coding RNAs (sRNAs) are closely related to important processes including metabolism, quorum sensing, virulence, and fitness. Studies conducted  in silico  and experiments using microarrays and high-throughput RNA sequencing have led to the discovery of an unexpected number of sRNAs in  Vibrios . The present review discusses the most relevant reports regarding the mechanisms of action of sRNAs and their implications in the virulence of the main human pathogens in the family  Vibrionaceae: Vibrio parahaemolyticus, V. vulnificus  and  V. cholerae .

Role of Non-coding Regulatory RNA in the Virulence of Human Pathogenic Vibrios