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The conserved cAMP-dependent protein kinase (PKA) is composed of the regulatory and catalytic subunits and acts as the central component of the cAMP signaling pathway. In the human fungal pathogen  Candida albicans , the PKA regulatory subunit Bcy1 plays a critical role in the regulation of cell differentiation and death. It has long been considered that Bcy1 is essential for cell viability in  C. albicans . In the current study, surprisingly, we found that Bcy1 is not required for cell growth, and we successfully generated a  bcy1/bcy1  null mutant in  C. albicans . Deletion of  BCY1  leads to multiple cellular morphologies and promotes the development of filaments. Filamentous and smooth colonies are two typical morphological types of the  bcy1/bcy1  mutant, which can undergo spontaneous switching between the two types. Cells of filamentous colonies grow better on a number of different culture media and have a higher survival rate than cells of smooth colonies. In addition, deletion of  BCY1  significantly increased the frequency of white-to-opaque switching on N-acetylglucosamine (GlcNAc)-containing medium. The  bcy1/bcy1  null mutant generated herein provides the field a new resource to study the biological functions of the cAMP signaling pathway in  C. albicans .

frontiers in microbiology

The Regulatory Subunit of Protein Kinase A (Bcy1) in Candida albicans Plays Critical Roles in Filamentation and White-Opaque Switching but Is Not Essential for Cell Growth