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CLIBASIA_01510, PrbP, is a predicted RNA polymerase binding protein in  Liberibacter asiaticus . PrbP was found to regulate expression of a small subset of ribosomal genes through interactions with the β-subunit of the RNA polymerase and a short, specific sequence on the promoter region. Molecular screening assays were performed to identify small molecules that interact with PrbP  in vitro . Chemical hits were analyzed for therapeutic efficacy against  L. asiaticus  via an infected leaf assay, where the transcriptional activity of  L. asiaticus  was found to decrease significantly after exposure to tolfenamic acid. Similarly, tolfenamic acid was found to inhibit  L. asiaticus  infection in highly symptomatic citrus seedlings. Our results indicate that PrbP is an important transcriptional regulator for survival of  L. asiaticus in planta , and the chemicals identified by molecular screening assays could be used as a therapeutic treatment for huanglongbing disease.

Drug Repurposing: Tolfenamic Acid Inactivates PrbP, a Transcriptional Accessory Protein in Liberibacter asiaticus