English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Humans are continuously exposed to airborne spores of the saprophytic fungus  Aspergillus fumigatus . However, in healthy individuals pulmonary host defense mechanisms efficiently eliminate the fungus. In contrast,  A. fumigatus  causes devastating infections in immunocompromised patients. Host immune responses against  A. fumigatus  lung infections in immunocompromised conditions have remained largely elusive. Given the dynamic changes in immune cell subsets within tissues upon immunosuppressive therapy, we dissected the spatiotemporal pulmonary immune response after  A. fumigatus  infection to reveal basic immunological events that fail to effectively control invasive fungal disease. In different immunocompromised murine models, myeloid, notably neutrophils, and macrophages, but not lymphoid cells were strongly recruited to the lungs upon infection. Other myeloid cells, particularly dendritic cells and monocytes, were only recruited to lungs of corticosteroid treated mice, which developed a strong pulmonary inflammation after infection. Lymphoid cells, particularly CD4 +  or CD8 +  T-cells and NK cells were highly reduced upon immunosuppression and not recruited after  A. fumigatus  infection. Moreover, adoptive CD11b +  myeloid cell transfer rescued cyclophosphamide immunosuppressed mice from lethal  A. fumigatus  infection but not cortisone and cyclophosphamide immunosuppressed mice. Our findings illustrate that CD11b +  myeloid cells are critical for anti- A. fumigatus  defense under cyclophosphamide immunosuppressed conditions.

Dynamic Immune Cell Recruitment After Murine Pulmonary Aspergillus fumigatus Infection under Different Immunosuppressive Regimens