English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Manganese (Mn 2+ )-, zinc (Zn 2+ )- and copper (Cu 2+ ) play significant roles in transcriptional gene regulation, physiology, and virulence of  Streptococcus pneumoniae . So far, the effect of the important transition metal ion cobalt (Co 2+ ) on gene expression of  S. pneumoniae  has not yet been explored. Here, we study the impact of Co 2+  stress on the transcriptome of  S. pneumoniae  strain D39. BLAST searches revealed that the genome of  S. pneumoniae  encodes a putative Co 2+ -transport operon ( cbi  operon), the expression of which we show here to be induced by a high Co 2+  concentration. Furthermore, we found that Co 2+ , as has been shown previously for Zn 2+ , can cause derepression of the genes of the PsaR virulence regulon, encoding the Mn 2+ -uptake system PsaBCA, the choline binding protein PcpA and the cell-wall associated serine protease PrtA. Interestingly, although Mn 2+  represses expression of the PsaR regulon and Co 2+  leads to derepression, both metal ions stimulate interaction of PsaR with its target promoters. These data will be discussed in the light of previous studies on similar metal-responsive transcriptional regulators.

frontiers in microbiology

Co2+-dependent gene expression in Streptococcus pneumoniae: opposite effect of Mn2+ and Co2+ on the expression of the virulence genes psaBCA, pcpA, and prtA