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Vitamin C is a critical dietary nutrient in human which has a wide range of regulatory effects on gene expression and physiology of  Mycobacterium tuberculosis  that leads to a dormant drug-tolerant phenotype. In the presence of iron, vitamin C shows a high bactericidal activity even in the drug resistant phenotype of  M. tuberculosis . The regulatory mechanisms underlying vitamin C induced adaptations are largely unknown due to lack of functional genomics data in this field. In this study, we attempt to characterize the direct effect of vitamin C treatment on the physiology of actively growing  Mycobacterium smegmatis . The study chose  M. smegmatis  as it is a fast-growing bacterium and a non-pathogenic model system which shares many physiological features with the pathogenic  M. tuberculosis  including dormancy and its regulation. The proteomic adaptation of  M. smegmatis  on vitamin C treatment demonstrates the important changes in cellular and metabolic process such as reversal of tricarboxylic acid cycle, decrease in ATP synthesis, decrease in iron acquisition and storage, and induction of dormancy regulators WhiB3, PhoP, and Lsr2.

Qualitative and quantitative proteomic analysis of Vitamin C induced changes in Mycobacterium smegmatis