English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Single-nucleotide polymorphisms (SNPs) associated with hepatitis C virus (HCV) clearance were identified near the  IL28B  gene. Coinfection by the human immunodeficiency virus (HIV) influences the course of HCV contributing to liver damage. Nevertheless, little is known about the relationship between these SNPs and HCV/HIV coinfection. Our aim was to estimate the frequencies of the allelic and genotypic variants of the  IL28B  polymorphisms rs12979860 ( C / T ) and rs8099917 ( T / G ) and their possible association with the establishment of HCV infection.   Methodology:  A total of 199 non-infected controls and 230 patients with chronic hepatitis C, including 53 coinfected with HIV, participated in the study. Genotyping consisted of polymerase chain reaction and subsequent analysis of the restriction patterns resulting from exposure to endonucleases.   Results:  Among the controls with established results, 47.4% (90/190) exhibited the rs12979860  CC  genotype, 43.7  CT , and 8.9%  TT , whereas 29.1% (66/227), 51.5%, and 19.4% of the patients exhibited the  CC ,  CT , and  TT  genotypes, respectively. With respect to rs8099917, 66.8% (133/199) of the controls exhibited the  TT  genotype, 31.2%  TG , and 2.0%  GG , whereas 56.1% (129/230), 40.9%, and 3.0% of the patients exhibited the  TT ,  TG , and  GG  genotypes, respectively.   Conclusion:  The frequencies of the rs12979860  C  allele and  CC  genotype and of the rs8099917  T  allele and  TT  genotype were significantly higher among controls compared with patients, thus confirming the suggested protective effect against HCV infection. No significant difference was observed in the genotype and allelic distributions between the mono- and coinfected patients.

IL28B gene polymorphisms in mono- and HIV-coinfected chronic hepatitis C patients