English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Campylobacter jejuni  is an important foodborne pathogen. The molecular mechanisms for the regulation of oxidative stress resistance have not yet been understood fully in this bacterium. In this study, we investigated how PerR (peroxide stress regulator) modulates the transcriptional regulation of both peroxide and superoxide resistance genes in  C. jejuni , particularly under oxidative stress conditions. The transcriptional levels of  ahpC ,  katA , and  sodB  were substantially increased by aeration and oxidant exposure. Interestingly, a  perR  mutation completely abrogated the transcriptional response of  ahpC ,  katA  and  sodB  to oxidants. Furthermore, we demonstrated that  perR  transcription was reduced by aeration and oxidant exposure. In contrast to the unique role of PerR homologs in peroxide stress regulation in other bacteria,  C. jejuni  PerR directly regulates the transcription of  sodB , the most important gene in superoxide defense, as evidenced by the alteration of  sodB  transcription by the  perR  mutation and direct binding of rPerR to the  sodB  promoter. In addition, we also observed notable morphological changes in  C. jejuni  from spiral rods to cocoid morphology under aerobic conditions. Based on the intracellular ATP levels,  C. jejuni  entered a viable-but-non-culturable (VBNC) state under aerobic conditions. These findings clearly demonstrate that  C. jejuni  possesses a unique regulatory mechanism of oxidative stress defense that does not specifically distinguish between peroxide and superoxide defense, and PerR plays a pivotal role in this non-selective regulation of oxidative stress resistance in  C. jejuni .

Non-selective regulation of peroxide and superoxide resistance genes by PerR in Campylobacter jejuni