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Our previous study manifested that lanthanum chloride (LaCl 3 ) can enhance the anticancer ability of cisplatin (DDP) in ovarian cancer cells. Here, ovarian cancer cells SKOV3 and SKOV3/DDP were subjected to DDP and LaCl 3 . Cell viability, apoptosis, DNA repair, and PI3K/Akt pathway were detected. LaCl 3  induced more cell death and apoptosis caused by DDP in two cell lines, accompanied by upregulation of Bax and Cleaved caspase 3 proteins, and downregulation of Bcl-2 protein. LaCl 3  also could decrease RAD51 protein by inactivation of the PI3K/Akt pathway. These data indicated that LaCl 3  could be a potential drug to modulate DDP resistance by inactivating of PI3K/Akt pathway and attenuating DNA repair in ovarian cancer.

Lanthanum Chloride Sensitizes Cisplatin Resistance of Ovarian Cancer Cells via PI3K/Akt Pathway