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Objectives:  The aim of this research was to investigate the clinical and microbiological characteristics of a case of community-acquired carbapenem-resistant  Escherichia coli  isolated from a patient with a bloodstream infection in China.   Methods:   Escherichia coli  Huamei202001 was recovered from the first blood culture from a patient hospitalised in China. An antimicrobial susceptibility test was performed, and the genome was sequenced on an Illumina HiSeq X 10 platform with a 150-bp paired-end approach. The generated sequence reads were assembled using Unicycler, and the whole genome sequence data were analysed using bioinformatics tools. Moreover, the patient and her main family members obtained a faecal sample screening test for CRE, the positive strain was further isolated and the identification and antimicrobial susceptibility testing was performed.   Results:   Escherichia coli  Huamei202001 belonged to sequence type 410. In addition, a  bla NDM-5-encoding IncX3-type plasmid was responsible for the spreading of carbapenem resistance. Only the patient was detected as having a positive faecal sample screening test for CRE. Strain Fec01 was identified as  E. coli , and the antibiotic susceptibility profile was the same as that of  E. coli  Huamei202001.   Conclusions:   Escherichia coli  Huamei202001 is defined as community-acquired carbapenem-resistant Enterobacteriaceae. The clone ST410 that harbours the  bla NDM-5-encoding IncX3-type plasmid is causing new high-risk clones globally. Thus, infection control measures should be strengthened to curb the dissemination of IncX3.

frontiers in medicine

Clinical and Microbiological Characteristics of a Community-Acquired Carbapenem-Resistant Escherichia coli ST410 Isolate Harbouring blaNDM-5-Encoding IncX3-Type Plasmid From Blood