English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background:  Bowel preparation is necessary for successful colonoscopy, while it can seriously affect intestinal microbial composition and damage the intestinal mucosal barriers in humans.   Methods:  To figure out whether probiotics can sustain intestinal homeostasis and guard people's health, the probiotic drug of  Bifidobacterium  Tetragenous viable Bacteria Tablets (P group,  n  = 16) or placebo (C group,  n  = 16) was used for volunteers receiving bowel preparation, and high-throughput sequencing method was applied to monitor their intestinal microbial changes.   Results:  The present results suggested that bowel preparation obviously reduced the intestinal microbial diversity, while taking probiotics significantly restored it to normal level. In addition, probiotics sharply reduced the abundance of pathogenic  Proteobacteria , and obviously lowered the ratio of  Firmicutes/Bacteroidetes  compared with control group at phylum level ( P  < 0.05). And probiotics markedly decreased the abundance of pathogenic  Acinetobacter  and  Streptococcus , while greatly enriched the relative abundance of beneficial bacteria  Bacteroides, Roseburia, Faecalibacterium , and  Parabacteroides  at genus level ( P  < 0.05).   Conclusion:  Probiotic drugs, e.g.,  Bifidobacterium  Tetragenous viable Bacteria Tablets, can be used to restore intestinal dysbacteriosis caused by bowel preparation, and reduce side effects during colonoscopy.

Oral Probiotics Alleviate Intestinal Dysbacteriosis for People Receiving Bowel Preparation