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Aims  To evaluate the role of human leukocyte antigen (HLA) class II  DQB1*0201  and  DQA1*0102  in the risk of antituberculosis drug (ATD)-induced hepatotoxicity (ATDH) in a cohort of tuberculosis patients of Caucasian origin from Spain.    Methods  Matched case-control study including active tuberculosis (TB) patients from Spain (Caucasian) treated with first-line ATD (Isoniazid, Rifampin, and Pyrazinamide). Presence or absence of HLA class II  DQB1*0201  and  DQA1*0102  alleles were compared between cases and controls.    Results  We included 110 TB patients, 55 ATDH cases, and 55 sex-matched controls. The analysis of the presence of  HLA-DQB1*0201  and  HLA-DQA*0102  did not show significative differences between both groups [presence of  HLA-DQB1*0201  53.6% of the cases vs. 45.4% of the controls, OR: 1.63 95% CI (0.62–4.52)  p  = 0.38; presence of  HLA-DQA* 0102 7.5% of cases vs. 20% of controls, OR: 0.36 95% CI (0.08–1.23)  p  = 0.12]. After multivariate logistic regression analysis including in the model, other potential risk factors of hepatotoxicity HLA class II  DQB1*0201  and  DQA1*0102  alleles were not found significantly associated with the risk of development ATDH. We could not demonstrate an association between  HLA-DQA1*0102  and  HLA-DQB1*0201  with the risk of ATDH in this Caucasian population of Spanish origin.

HLA-DQ B1*0201 and A1*0102 Alleles Are Not Responsible for Antituberculosis Drug-Induced Hepatotoxicity Risk in Spanish Population

HLA-DQ B10201 and A10102 Alleles Are Not Responsible for Antituberculosis Drug-Induced Hepatotoxicity Risk in Spanish Population