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Cheap, easy-to-produce oral vaccines are needed for control of coccidiosis in chickens to reduce the impact of this disease on welfare and economic performance.  Saccharomyces cerevisiae  yeast expressing three  Eimeria tenella  antigens were developed and delivered as heat-killed, freeze-dried whole yeast oral vaccines to chickens in four separate studies. After vaccination,  E. tenella  replication was reduced following low dose challenge (250 oocysts) in Hy-Line Brown layer chickens (p&amp;lt;0.01). Similarly, caecal lesion score was reduced in Hy-Line Brown layer chickens vaccinated using a mixture of S. cerevisiae expressing EtAMA1, EtIMP1 and EtMIC3 following pathogenic-level challenge (4,000  E. tenella  oocysts; p&amp;lt;0.01). Mean body weight gain post-challenge with 15,000  E. tenella  oocysts was significantly increased in vaccinated Cobb500 broiler chickens compared to mock-vaccinated controls (p&amp;lt;0.01). Thus, inactivated recombinant yeast vaccines offer cost-effective and scalable opportunities for control of coccidiosis, with relevance to broiler production and chickens reared in low-and middle-income countries (LMICs).

A Novel Whole Yeast-Based Subunit Oral Vaccine Against Eimeria tenella in Chickens