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TCRαβ + CD8αα +  intraepithelial lymphocytes (IELs) are abundant in gastrointestinal (GI) tract and play an important role in regulation of mucosal immunity and tolerance in the gut. However, it is unknown whether TCRαβ + CD8αα +  IELs exist in the oral mucosa and if yes, what controls their development. We here identified and characterized TCRαβ + CD8αα +  IELs from the murine oral mucosa. We showed that the number and function of TCRαβ + CD8αα +  IELs were regulated by TGF-β. We further revealed that oral TCRαβ + CD8αα +  IELs could be altered under systemic inflammatory conditions and by antibiotic treatment at the neonatal age of the mice. Our findings have revealed a previously unrecognized population of oral IELs that may regulate oral mucosal immune responses.

Identification and Regulation of TCRαβ+CD8αα+ Intraepithelial Lymphocytes in Murine Oral Mucosa