English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The discovery that cancer cells are recognized and targeted by the immune system has recently increased interest in cancer immunotherapies. Currently, the most widely used immunotherapy is immune checkpoint blockade using monoclonal antibodies to block intrinsic downregulators of immunity, which are often over-expressed in cancer. Although beneficial to some patients, the majority do not respond to this treatment (1), highlighting the need for new, novel, strategies. One new approach is T-cell therapy with genetically engineered T cells to generate an effective antitumor immune response through ex vivomanipulation of the T-cell tumor-specificity. This can be accomplished by gene transfer of T-cell receptors (TCRs) or chimeric antigen receptors (CARs) into autologous T cells before reinfusing them into the patient. CAR T-cell therapy has shown excellent results in the treatment of some B-cell malignancies, but the lack of suitable antigens presents a challenge to transferring this therapy to other malignancies, including solid cancers (2). Here, we review data on cancer/testis (CT) antigens as targets for CAR T-cell therapy and present a strategy to upregulate CT antigen expression on tumor cells via epigenetic treatment to sensitize cancer cells to CAR T-cell therapy (Figure 1).

CAR T-Cell Cancer Therapy Targeting Surface Cancer/Testis Antigens