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CD11c +  B cells have been reported to be increased in autoimmune diseases, but they are detected in the blood of healthy individuals as well. We aimed to characterize CD11c +  B cells from healthy donors by flow cytometry, microarray analysis, and  in vitro  functional assays. Here, we report that CD11c +  B cells are a distinct subpopulation of B cells, enriched in the memory subpopulation even if their phenotype is heterogeneous, with overexpression of genes involved in B-cell activation and differentiation as well as in antigen presentation. Upon activation, CD11c +  B cells can differentiate into antibody-secreting cells, and CD11c could be upregulated in CD11c −  B cells by B-cell receptor activation. Finally, we show that patients with pemphigus, an autoimmune disease mediated by B cells, have a decreased frequency of CD11c +  B cell after treatment, relative to baseline. Our findings show that CD11c +  B cells are mainly memory B cells prone to differentiate into antibody secreting cells that accumulate with age, independently of gender.

CD11c+ B Cells Are Mainly Memory Cells, Precursors of Antibody Secreting Cells in Healthy Donors