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NLRP10 is a nucleotide-binding oligomerization domain-like receptor that functions as an intracellular pattern recognition receptor for microbial products. Here, we generated a  Nlrp10 −/−   mouse to delineate the role of NLRP10 in the host immune response and found that  Nlrp10 −/−   dendritic cells (DCs) elicited sub-optimal IFNγ production by antigen-specific CD4 +  T cells compared to wild-type (WT) DCs. In response to T-cell encounter, CD40 ligation or Toll-like receptor 9 stimulation,  Nlrp10 −/−   DCs produced low levels of IL-12, due to a substantial decrease in NF-κB activation. Defective IL-12 production was also evident  in vivo  and affected IFNγ production by CD4 +  T cells. Upon  Mycobacterium tuberculosis  ( Mtb ) infection,  Nlrp10 −/−   mice displayed diminished T helper 1-cell responses and increased bacterial growth compared to WT mice. These data indicate that NLRP10-mediated IL-12 production by DCs is critical for IFNγ induction in T cells and contributes to promote the host defense against  Mtb .

NLRP10 Enhances CD4+ T-Cell-Mediated IFNγ Response via Regulation of Dendritic Cell-Derived IL-12 Release