English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The absence of anti-cytomegalovirus (CMV) immunoglobulin G (IgG) is used to classify pretransplant patients as naïve for CMV infection (CMV neg  patients). This study assessed whether pretransplant CMV-specific T-cell immunity exists in CMV neg  patients and whether it protects against CMV infection after kidney transplantation. The results show that CMV-specific CD137 + IFNγ + CD4 +  and CD137 + IFNγ + CD8 +  memory T cells were present in 46 and 39% of CMV neg  patients ( n  = 28) although at much lower frequencies compared to CMV pos  patients (median 0.01 versus 0.58% for CD4 +  and 0.05 versus 0.64% for CD8 +  T cells) with a less differentiated CD28-expressing phenotype. In line with these data, CMV-specific proliferative CD4 +  and CD8 +  T cells were observed in CMV neg  patients, which significantly correlated with the frequency of CMV-specific T cells. CMV-specific IgG antibody-secreting cells (ASC) could be detected at low frequency in 36% of CMV neg  patients (1 versus 45 ASC/10 5  cells in CMV pos  patients). CMV neg  patients with pretransplant CMV-specific CD137 + IFNγ + CD4 +  T cells had a lower risk to develop CMV viremia after transplantation with a CMV pos  donor kidney (relative risk: 0.43,  P  = 0.03). In conclusion, a solitary CMV-specific T-cell response without detectable anti-CMV antibodies is frequent and clinically relevant as it is associated with protection to CMV infection following transplantation with a kidney from a CMV pos  donor.

Protective Cytomegalovirus (CMV)-Specific T-Cell Immunity Is Frequent in Kidney Transplant Patients without Serum Anti-CMV Antibodies