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Dietary polyphenols exert a range of beneficial outcomes on the intestinal microbiota, and in metabolic syndrome, such as anti-inflammatory, antioxidant, anticarcinogenic, and antidiabetic effects. Research by Roopchand and colleagues demonstrated that concord grape polyphenols (GP) led to changes in the gut microbiota and reduction in conditions associated with metabolic syndrome arising from high-fat diet (HFD) in mice (1). Mice were divided into three groups and fed with HFD only or HFD supplemented with 10% soy-protein isolate (SPI) or HFD supplemented with 10% GP-SPI, respectively, for 13 weeks. When compared to the other diet groups, mice on the GP-SPI diet had lower body weight and adiposity though the food intake was similar across the groups (1).

Commentary: Dietary Polyphenols Promote Growth of the Gut Bacterium Akkermansia muciniphila and Attenuate High-Fat Diet-Induced Metabolic Syndrome