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The cytokine IL-10 plays a crucial role during malaria infection by counteracting the pro-inflammatory immune response. We and others demonstrated that  Plasmodium yoelii  infection results in enhanced IL-10 production in CD4 +  T cells accompanied by the induction of an immunosuppressive phenotype. However, it is unclear whether this is a direct effect caused by the parasite or an indirect consequence due to T cell activation by IL-10-producing antigen-presenting cells. Here, we demonstrate that CD11c + CD11b + CD8 −  dendritic cells (DCs) produce elevated levels of IL-10 after  P. yoelii  infection of BALB/c mice. DC-specific ablation of IL-10 in  P. yoelii -infected IL-10 flox/flox /CD11c-cre mice resulted in increased IFN-γ and TNF-α production with no effect on MHC-II, CD80, or CD86 expression in CD11c +  DCs. Accordingly, DC-specific ablation of IL-10 exacerbated systemic IFN-γ and IL-12 production without altering  P. yoelii  blood stage progression. Strikingly, DC-specific inactivation of IL-10 in  P. yoelii -infected mice interfered with the induction of IL-10-producing CD4 +  T cells while raising the frequency of IFN-γ-secreting CD4 +  T cells. These results suggest that  P. yoelii  infection promotes IL-10 production in DCs, which in turn dampens secretion of pro-inflammatory cytokines and supports the induction of CD4 + IL-10 +  T cells.

frontiers in immunology

DC-Derived IL-10 Modulates Pro-inflammatory Cytokine Production and Promotes Induction of CD4+IL-10+ Regulatory T Cells during Plasmodium yoelii Infection