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Regulatory T cells expressing the transcription factor Foxp3 require acquisition of a specific hypomethylation pattern to ensure optimal functional commitment, limited lineage plasticity, and long-term maintenance of tolerance. A better understanding of the molecular mechanisms involved in the generation of these epigenetic changes  in vivo  will contribute to the clinical exploitation of Foxp3 +  Treg. Here, we show that both  in vitro  and  in vivo  generated antigen-specific Foxp3 +  Treg can acquire Treg-specific epigenetic characteristics and prevent skin graft rejection in an animal model.

Induced Foxp3+ T Cells Colonizing Tolerated Allografts Exhibit the Hypomethylation Pattern Typical of Mature Regulatory T Cells